The Premier League's top goalscorer has had a groin problem and sat out the draw at Newcastle and Saturday's victory over Everton.
Midfielders Darren Fletcher and Owen Hargreaves remain unavailable and Bebe also misses out.
However, John O'Shea took his place on the plane despite leaving the field with an injury against the Toffees and a third goalkeeper has still to be confirmed.
Squad: Edwin van der Sar, Tomasz Kuszczak; Patrice Evra, Wes Brown, Chris Smalling, Rio Ferdinand, John O'Shea, Jonny Evans, Nemanja Vidic, Fabio, Rafael; Anderson, Ryan Giggs, Ji-sung Park, Michael Carrick, Nani, Paul Scholes, Antonio Valencia, Gabriel Obertan, Darron Gibson; Michael Owen, Wayne Rooney, Javier Hernandez.
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